Virion protein 26 from Kaposi's sarcoma-associated herpesvirus, DNA encoding same and uses thereof

US5859225A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yuan Chang · New York, US
• Roy A. Bohenzky · Mountain View, US
• James J. Russo · New York, US
• Isidore S. Edelman · New York, US
• Patrick S. Moore · New York, US

Key dates

• Filing date: Sep 5, 1996
• Grant date: Jan 12, 1999
• Expiry date: Sep 5, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16422
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides an isolated nucleic acid molecule which encodes KSHV virion protein 26. This invention provides an isolated polypeptide molecule which encodes KSHV virion protein 26. This invention provides an antibody specific to the polypeptide. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine and method of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.