Synthesis of oligonucleotides with boranophosphonate linkages
US5859231A · kind A · utility
19Cited by
11References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 16, 1996 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Sep 16, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates, in general, to a process of enzymatically synthesizing nucleic acids containing boranophosphonate linkages that are resistant to degradation. The invention further relates to methods of utilizing such nucleic acids in DNA and RNA amplification and sequencing, gene therapy and molecular detection protocols.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.