Process to chloroketones using oxazolines
US5859254A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 13, 1998 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Apr 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a process for the preparation of an .alpha.-chloroketone compound comprising the steps of PA1 (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate ##STR2## and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone ##STR3## wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, PA1 R is a hydrogen atom or alkyl, and PA1 R.sup.1 and R.sup.2 are each independently an alkyl or substituted alkyl group, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a cyclic structure. Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.