Preparation of high purity sodium (S)-2(6-methoxy-2-naphthyl)propionate
US5859292A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 11, 1997 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Dec 11, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/412
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Sodium (S)-2-(6-methoxy-2-naphthyl)propionate of at least 99% chiral purity is formed from (S)-2-(6-methoxy-2-naphthyl)propionic acid having a chiral purity of at least about 82%, but below 99%. This is done by distilling a two-phase mixture formed from (i) the (S)-2-(6-methoxy-2-naphthyl)propionic acid, (ii) water, (iii) sodium hydroxide, sodium oxide and/or at least one basic inorganic sodium salt in an amount proportioned to neutralize from about 50 to about 99% of said acid, and optionally but preferably, (iv) an inert organic solvent that has a boiling point of at least 95.degree. C. at 760 mm Hg such that water is removed from said mixture, and a pot residue containing sodium (S)-2-(6-methoxy-2-naphthyl)propionate of at least 99% chiral purity is formed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.