Transgenic non-human animals having targeting endogenous lymphocyte transduction genes and cognate human transgenes
US5859312A · kind A · utility
39Cited by
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8Claims
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Key dates
| Filing date | Jul 8, 1996 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Jul 8, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides transgenic non-human animals and transgenic non-human mammalian cells having at least one functionally disrupted lymphocyte transduction locus, particularly a CD4 locus, targeting constructs used to produce such transgenic stem cells and animals, methods and targeting constructs for inactivating or suppressing expression of endogenous lymphocyte transduction gene loci, transgenes encoding heterologous lymphocyte transduction proteins, and nonhuman animals that express a human lymphocyte transduction protein and lack expression of a cognate murine lymphocyte transduction protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.