Patent · US Expired

Long-lasting release nifedipine preparation

US5861173A · kind A · utility

28Cited by

3References

12Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Takaaki Nishioka · Kobe, JP
Kenji Kuratani · Moriyama, JP
Haruo Kanasaki · Moriyama, JP
Helmut Luchtenberg · Niederkassel, DE
Ulrich Tenter · Solingen, DE
Andreas Ohm · Neuss, DE

Key dates

Filing date	Nov 21, 1996
Grant date	Jan 19, 1999
Priority date	—
Expiry date	Nov 21, 2016

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan, after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan, after 3 hours 20-45% after 4 hours 30-65%.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.