Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications

US5861257A · kind A · utility

Assignee

• N.V. Innogenetics S.A. · BE

Inventors

• Marc Vandermeeren · Geel, BE
• Marc Mercken · Turnhout, BE
• Eugeen Vanmechelen · Zevergem, BE
• Andre Van De Voorde · Lokeren, BE

Key dates

• Filing date: Feb 15, 1995
• Grant date: Jan 19, 1999
• Expiry date: Feb 15, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/811
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a monoclonal antibody which forms an immunological complex with an epitope of an antigen belonging to normal human tau protein as well as abnormally phosphorylated human tau protein, with said tau protein being liable to be obtained from a brain homogenate, itself isolated from human cerebral cortex. The monoclonal antibodies of the invention can be used to detect tau and abnormally phosphorylated tau in brain extracts and in unconcentrated cerebrospinal fluid.