Antistasin type serine protease inhibitors

US5861377A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Hans Fritz · Höhenkirchen-Siegertsbrunn, DE
• Christian Sommerhoff · Hersbruck, DE
• Jutta Heim · Ramlinsburg, CH

Key dates

• Filing date: Jan 6, 1995
• Grant date: Jan 19, 1999
• Expiry date: Jan 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel inhibitors belonging to the family of antistasin-type serine proteinase inhibitors, to their isolation from the medical leech Hirudo medicinalis, to DNA sequences encoding the novel inhibitors, to variants obtained by recombinant DNA technology or peptide synthesis, pharmaceutical compositions containing the inhibitors, and to their use in diagnosis and therapy.