Use of N-substituted phenothiazines

US5861394A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Klaus Urbahns · Kasai, JP
• Hans-Georg Heine · Krefeld, DE
• Bodo Junge · Wuppertal, DE
• Rudolf Schohe-Loop · Wuppertal, DE
• Henning Sommermeyer · Neunburg vorm Wald, DE
• Thomas Glaser · Overath, DE
• Reilinde Wittka · Neunburg vorm Wald, DE
• Jean De Vry · Stolberg, DE

Key dates

• Filing date: Feb 19, 1997
• Grant date: Jan 19, 1999
• Expiry date: Feb 19, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D279/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the use of N-substituted phenothiazines for the production of medicaments for the treatment of cerebral disorders. The invention likewise relates to novel active compounds which are prepared by reaction of phenothiazine with the appropriate acids, esters or amides or by reaction of the phenothiazinecarbonyl halides with amines. The active compounds are particularly suitable for the treatment of dementias and age-related leaning and memory disorders and depressions.