Nitro compounds of the formula A-X.sub.i -NO.sub.2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
US5861426A · kind A · utility
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Key dates
| Filing date | Mar 6, 1997 |
| Grant date | Jan 19, 1999 |
| Priority date | — |
| Expiry date | Mar 6, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/24
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A--X.sub.1 --NO.sub.2 or their salts, wherein: A is R(COX.sub.u).sub.t, wherein t is zero or 1 and u is zero or 1; and X is O, NH or NR.sub.1C wherein R.sub.1C is C.sub.1 -C.sub.10 alkyl; and R is(Ia) wherein R.sub.1 is acetoxoy, preferably n ortho-position with respect to --CO-- and R.sub.2 is hydrogen; or derivatives of acetylsalylsalicyclic acid; and X.sub.1 is --YO-- wherein Y is C.sub.1 -C.sub.20 alkylene, C.sub.5 -C.sub.7 cycloalkylene, oxy-alkyl derivatives and oxy-methyl benzyl derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.