Process for the preparation of taxane derivatives
US5861515A · kind A · utility
3Cited by
2References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 31, 1997 |
| Grant date | Jan 19, 1999 |
| Priority date | — |
| Expiry date | Oct 31, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a method of preparing taxane derivatives of formula (VIII) by esterification of protected baccatin III or 10-deacetylbaccatin III by means of an acid of formula (VII), elimination of protection groupings and acylation of the amine function of the side chain. In formulae (VIII) and (VII): Ar stands for aryl, R.sub.3 is a trihalomethyl radical or phenyl substituted by a trihalomethyl radical, R.sub.4 is a hydrogen atom or is the same as R.sub.1. G.sub.1 and G.sub.2 are hydroxy protecting groups. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.