Composition and method of MRI using both a positive and a negative contrast agent

US5863519A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Klaes Golman · Hørsholm, DK
• Goran Pettersson · Hjärup, SE
• Arne Berg · Sandvika, NO
• Jo Klaveness · Oslo, NO
• Pal Rongved · Oslo, NO
• Peter Leander · Lund, SE
• Ib Leunbach · Copenhagen, DK
• Wolfgang H. H. Gunther · Hersbruck, DE

Key dates

• Filing date: Feb 16, 1996
• Grant date: Jan 26, 1999
• Expiry date: Feb 16, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/1863
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is provided a contrast medium composition comprising: (a) a first contrast agent comprising a physiologically tolerable manganese compound together with an uptake promoter, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese, wherein the uptake promoter comprises a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group or a physiologically tolerable acid containing .alpha.- and/or .beta.- hydroxy or amino groups, or a salt thereof, and/or vitamin D; together with (b) a second contrast agent. Such compositions are particularly suitable for imaging of the liver.