Method for identifying inhibitors of cdc2 protein kinase from pneumocystis carinii
US5863741A · kind A · utility
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Key dates
| Filing date | Jun 13, 1997 |
| Grant date | Jan 26, 1999 |
| Priority date | — |
| Expiry date | Jun 13, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4739
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A nucleic acid and corresponding polypeptide that aids in the regulation of the cell cycle in Pneumocystis carinii is described. Antibodies generated against a unique carboxyl-terminus region of the polypeptide have specific binding affinity for P. carinii Cdc2 polypeptide and are beneficial in diagnosing and monitoring P. carinii infection in patients. Expression of P. carinii Cdc2 polypeptide in cdc2-mutant yeast and other cdc2-mutant organisms provides a useful model for studying the life cycle of P. carinii and for identifying novel therapeutics.
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