Nucleic acid encoding novel receptor-type phosphotyrosine phosphatase-.kappa.

US5863755A · kind A · utility

Assignees

• Max-Planck-Gesellschaft · DE
• New York University Medical Center · US

Inventors

• Joseph Schlessinger · New York, US
• Jan M. Sap · New York, US
• Axel Ullrich · Portola Valley, US
• Wolfgang Vogel · Glastonbury, US
• Miriam Fuchs · Starnberg, DE

Key dates

• Filing date: Jul 1, 1993
• Grant date: Jan 26, 1999
• Expiry date: Jul 1, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/705
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A novel receptor-type protein tyrosine phosphatase-.kappa. (RPTP.kappa.) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. The RPTP.kappa. protein or glycoprotein may be produced by recombinant means. Antibodies to the protein, methods for measuring the quantity of the protein, methods for screening compounds, such as drugs, which can bind to the protein and inhibit or stimulate their enzymatic activity, are provided. Further, methods for inhibiting homophilic binding of Type II RPTP, especially RPTP.kappa. molecules are provided.