Nucleic acid encoding modified human tnf.alpha. (tumor necrosis factor alpha) receptor
US5863786A · kind A · utility
18Cited by
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8Claims
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Key dates
| Filing date | Jun 6, 1995 |
| Grant date | Jan 26, 1999 |
| Priority date | — |
| Expiry date | Jun 6, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A DNA molecule is provided which encodes a polypeptide which is capable of binding human TNF.alpha. and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the 55 kD and 75 kD receptors for human TNF.alpha.. The ability of the polypeptide to bind to TNF.alpha. means that it can be used for treating diseases mediated by TNF.alpha. activity, such as rheumatoid arthritis.
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