Use of bradykinin antagonists for the production of pharmaceuticals for the treatment of chronic fibrogenetic liver disorders and acute liver disorders

US5863901A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gerhard Breipohl · Scheinfeld, DE
• Stephan Henke · Bad Soden am Taunus, DE
• Jochen Knolle · Kriftel, DE
• Klaus Wirth · Frankfurt am Main, DE
• Max Hropot · Flörsheim, DE
• Martin Bickel · Frankfurt am Main, DE

Key dates

• Filing date: Mar 4, 1997
• Grant date: Jan 26, 1999
• Expiry date: Mar 4, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a method of treating a chronic fibrogenetic liver disorder and/or an acute liver disorder and/or complications associated therewith, comprising administering to a patient a therapeutically effective amount of a bradykinin antagonist. Particular complications associated with said liver disorders include portal hypertension, decompensation phenomena such as ascites, edema formation, hepatorenal syndrome, hypertensive gastropathy and colopathy, splenomegaly and hemorrhagic complications in the gastrointestinal tract due to portal hypertension, collateral circulation and hyperemia and a cardiopathy as a result of a chronically hyperdynamic circulatory situation and its consequences.