Purine and guanine derivatives

US5863921A · kind A · utility

Assignee

• Darwin Discovery Limited · GB

Inventors

• Steven Colin Beasley · Cambridge, GB
• John Gary Montana · Harlow, GB
• David Thomas Manallack · Cambridge, GB

Key dates

• Filing date: May 19, 1997
• Grant date: Jan 26, 1999
• Expiry date: May 19, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) ##STR1## wherein n=1 or 2; PA1 R.sup.1 is H, NH.sub.2 or halogen; PA1 R.sup.2 is H or NH.sub.2 ; PA1 R.sup.3 represents the group ##STR2## where m=0 or 1; R.sup.4 and R.sup.5 are the same or different and are each H, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, NHSO.sub.2 CF.sub.3, tetrazole, (CR.sup.6 R.sup.7).sub.p (Y).sub.q (CR.sup.6 R.sup.7).sub.t Z where (CR.sup.6 R.sup.7)p or (CR.sup.6 R.sup.7).sub.t may be straight or branched chain bearing the substituents R.sup.6 and R.sup.7 when p and t>1; R.sup.6 and R.sup.7 are the same or different and are each C.sub.0-6 alkyl-Z; PA1 p=1-3; PA1 q=0 or 1; PA1 t=0-4, provided that t>0 wgeb q=1; PA1 Y is NH, O, S(O)u where u=0-2; PA1 Z is H, CN, CO.sub.2 H, CO.sub.2 C.sub.1-6 alkyl, NHSO.sub.2 CF.sub.3, tetrazole, triazole, CONH.sub.2, CON(C.sub.1-6 alkyl).sub.2, CONH(C.sub.1-6 alkyl), SO.sub.2 NH (C.sub.1-6 alkyl) or SO.sub.2 N(C.sub.1-6 alkyl).sub.2 ; or a salt, soluate or hydrate thereof.