Increasing aqueous humor outflow
US5863948A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 23, 1994 |
| Grant date | Jan 26, 1999 |
| Priority date | — |
| Expiry date | Sep 23, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/365
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma, the method comprising topically administering to the eye an outflow-increasing amount of an analog of ethacrynic acid having a margin of safety of at least 2.0 and having the formula ##STR1## wherein each X.sub.1 and X.sub.2, independently, is a halogen, H, or CH.sub.3, or X.sub.1 and X.sub.2 together form a substituted or unsubstituted aromatic ring; X.sub.3 is an organic group; and X.sub.4 is OH or an organic group; provided that where X.sub.1 and X.sub.2 are Cl and X.sub.4 is OH, X.sub.3 cannot be 2-methylene-1-oxobutyl; or a pharmaceutically acceptable salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.