Process for the manufacture of 3-amino-substituted glycosylated bile acids
US5864022A · kind A · utility
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2References
26Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 24, 1997 |
| Grant date | Jan 26, 1999 |
| Priority date | — |
| Expiry date | Mar 24, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0027
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.