Multichannel, multipurpose sample collection and drug delivery system for laboratory animals
US5865766A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 10, 1997 |
| Grant date | Feb 2, 1999 |
| Priority date | — |
| Expiry date | Jan 10, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K29/00
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
A multichannel, multipurpose sample collection and drug delivery system for laboratory animals includes several sampling and/or infusion devices mounted on a powered turntable above the cage but out of the animal's sight. Probes are constructed using a unique four-channel design: this permits (a) the periodic infusion of drugs without the possibility of artifacts due to pressure shocks and (b) the addition of preservatives to the sample at the site of its collection. A simplified sample collection device stores samples in a coil of PTFE tubing, and a constant-pressure perfusion system serves microdialysis probes. Further advantageous embodiments of the present invention include (a) systems to measure feeding, drinking and motor activity; (b) automated and unattended systems for blood withdrawal and drug delivery; (c) a data link with a personal computer to provide for data acquisition and more sophisticated control; (d) an improved method for sampling extracellular concentrations of neuropeptides, which are difficult to measure with conventional microdialysis; (e) the capability to perform electrophysiology simultaneously with microdialysis (or other sampling methods); and (f) the …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.