Recombinant vaccine

US5866136A · kind A · utility

Assignees

• COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION · AU
• The Australian National University · AU

Inventors

• Ian Allister Ramshaw · Tuggeranong, AU
• David Bernard Boyle · Leopold, AU
• Barbara Elizabeth Coupar · Geelong, AU
• Marion Andrew · Brisbane, AU

Key dates

• Filing date: Nov 9, 1990
• Grant date: Feb 2, 1999
• Expiry date: Nov 9, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/24143
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A recombinant vaccine comprises a vaccine vector which incorporates a first nucleotide sequence capable of being expressed as all or a part of an antigenic polypeptide, together with a second nucleotide sequence capable of being expressed as all or a part of a lymphokine effective in enhancing the immune response to the antigenic polypeptide. The vaccine vectors include poxvirus, herpes virus or adenovirus, and the lymphokine may be an interleukin, tumour necrosis factor or gamma-interferon. The vaccine vector may express an antigenic polypeptide which is foreign to the host vector.