Nucleic acids encoding lymphoid CD30 antigen

US5866372A · kind A · utility

Inventors

• Harald Stein · Schaafheim, DE
• Horst Durkop · Berlin, DE
• Ute Latza · Berlin, DE

Key dates

• Filing date: Sep 8, 1994
• Grant date: Feb 2, 1999
• Expiry date: Sep 8, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The description relates to the lymphoid surface antigen CD30 (Ki-1) occurring in Hodgkin's disease, the protein sequence and the associated nucleotide sequence therein, manufacture thereof by genetic engineering, methods for diagnosis and investigation of Hodgkin's disease and use of these nucleotide sequences for producing transgenic animals. The invention provides methods not based on monoclonal antibodies for investigation and diagnosis of anaplastic large-cell lymphomas.