Human protein tyrosine phosphatase OB protein
US5866397A · kind A · utility
2Cited by
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7Claims
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Key dates
| Filing date | Feb 14, 1997 |
| Grant date | Feb 2, 1999 |
| Priority date | — |
| Expiry date | Feb 14, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/42
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This novel PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in osteoblasts. PTP-OB is involved in osteoblast differentiation, and modulators of PTP-OB activity in turn modulate osteoblast differentiation, osteoclast differentiation and osteoclast activity.
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