Cell line for propagating receptor binding site-deleted FMDV
US5866416A · kind A · utility
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1References
5Claims
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Key dates
| Filing date | Jun 24, 1996 |
| Grant date | Feb 2, 1999 |
| Priority date | — |
| Expiry date | Jun 24, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/32122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of making a genetically-engineered cell line which is susceptible to infection by foot-and-mouth disease virus and allows the virus to replicate is disclosed. The method involves fusing the DNA encoding ICAM-1 with the DNA encoding an antibody specific for foot-and-mouth disease virus and expressing the resulting chimeric cell surface receptor protein. The chimeric cell surface receptor protein allows foot-and-mouth disease virus to bind, leading to subsequent infection and replication of foot-and-mouth disease virus. A genetically-engineered cell which expresses the chimeric cell surface receptor protein is also claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.