Graphitic nanotubes in luminescence assays

US5866434A · kind A · utility

Assignee

• Meso Scale Technology LLP · US

Inventors

• Richard J. Massey · Rockville, US
• Mark Martin · Bethesda, US
• Liwen Dong · Rockville, US
• Ming Lu · Lanham, US
• Alan Fischer · Cambridge, US
• Fabian Jameison · Gaithersburg, US
• Pam Liang · Rockville, US
• Robert Hoch · Hensonville, US
• Jonathan K. Leland · Silver Spring, US

Key dates

• Filing date: Mar 6, 1996
• Grant date: Feb 2, 1999
• Expiry date: Mar 6, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/742
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Graphitic nanotubes, which include tubular fullerenes (commonly called "buckytubes") and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.