Cyclic adhesion inhibitors

US5866540A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Alfred Jonczyk · Darmstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Brunhilde Felding-Habermann · Village of La Jolla, US
• Guido Melzer · Hofheim, DE
• Beate Diefenbach · Darmstadt, DE
• David A. Cheresh · Village of La Jolla, US
• Horst Kessler · Schwalbach, DE
• Marion Gurrath · Garching bei München, DE
• Gerhard Müller · Krefeld, DE

Key dates

• Filing date: Jan 4, 1995
• Grant date: Feb 2, 1999
• Expiry date: Jan 4, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pharmaceutical compositions which contain at least one cyclopeptide of formula I (a)-(r): PA1 (a) cyclo(-Arg-Gly-Asp-D-Phe-Val-Ala); PA1 (b) cyclo(-Arg-Gly-Asp-D-Phe-Leu-Ala); PA1 (c) cyclo(-Arg-Gly-Asp-Phe-Val-D-Ala); PA1 (d) cyclo(-Arg-Gly-Asp-Phe-Leu-D-Ala); PA1 (e) cyclo(-Arg-Gly-Asp-D-Phe-Val-Gly); PA1 (f) cyclo(-Arg-Gly-Asp-D-Phe-Leu-Gly); PA1 (g) cyclo(-D-Arg-Gly-Asp-Phe-Val-Ala); PA1 (h) cyclo(-D-Arg-Gly-Asp-Phe-Val-Gly); PA1 (i) cyclo(-Arg-Gly-Asp-Phe-Pro-Gly); PA1 (j) cyclo(-Arg-Gly-Asp-Phe-D-Pro-Gly); PA1 (k) cyclo(-Arg-Gly-Asp-Phe-Pro-Ala); PA1 (l) cyclo(-Arg-Gly-Asp-Phe-D-Pro-Ala); PA1 (m) cyclo(-D-Arg-Gly-Asp-Phe-Val); PA1 (n) cyclo(-Arg-D-Ala-Asp-Phe-Val); PA1 (o) cyclo(-Arg-Gly-Asp-D-Phe-Val); PA1 (p) cyclo(-Arg-Ala-Asp-D-Phe-Val); PA1 (q) cyclo(-Arg-Gly-Asp-Phe-D-Val); PA1 (r) cyclo(-Arg-Gly-D-Asp-Phe-Val); or a salt thereof. The pharmaceutical compositions can be used as cell adhesion inhibitors, e.g., in the treatment of thrombosis, myocardial infarct, apoplexy, arteriosclerosis, inflammations, angina pectoris, and/or tumors.