7.alpha.-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7.alpha.-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents

US5866560A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Rolf Bohlmann · Berlin, DE
• Dieter Bittler · Berlin, DE
• Josef Heindl · Berlin, DE
• Nikolaus Heinrich · Berlin, DE
• Helmut Hofmeister · Berlin, DE
• Hermann Kunzer · Hermeskeil, DE
• Gerhard Sauer · Berlin, DE
• Christa Hegele-Hartung · Neheim, DE
• Rosemarie Lichtner · Berlin, DE
• Yukishige Nishino · Berlin, DE
• Karsten Parczyk · Berlin, DE
• Martin Schneider · Remchingen, DE

Key dates

• Filing date: Aug 20, 1997
• Grant date: Feb 2, 1999
• Expiry date: Aug 20, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J53/008
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention describes new, substituted 7.alpha.-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organic and inorganic acids. The new compounds represent compounds with very strong antiestrogenic action. The compounds according to the invention are, on the one hand, pure antiestrogens, or, on the other hand, antiestrogens with estrogenic partial action. Based on this spectrum of action, the new compounds are highly suitable for the production of pharmaceutical agents for tumor therapy and hormone replacement treatment.