Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them

US5866610A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans-Jochen Lang · Hofheim, DE
• Andreas Weichert · Egelsbach, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Wolfgang Scholz · Beverly, US
• Udo Albus · Florstadt, DE

Key dates

• Filing date: Jul 18, 1996
• Grant date: Feb 2, 1999
• Expiry date: Jul 18, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them. Described are benzoylguanidines of the formula I ##STR1## where R(1) to R(3) are H, Hal, (cyclo)alkyl, N.sub.3, CN or OH, alkyloxy, phenyl, phenoxy or benzoyl, and their pharmacologically acceptable salts, but with the exception of the compounds benzoylguanidine, 4-chlorobenzoylguanidine, 3,4-dichlorobenzoylguanidine and 3- or 4-methylbenzoylguanidine. They are obtained by reacting a compound II ##STR2## with guanidine, L being a leaving group.