Peptides that induce antibodies which neutralize genetically divergent HIV-1 isolates

US5866694A · kind A · utility

Assignee

• Hermann Katinger · AT

Inventors

• Hermann Katinger · Wien, AT
• Florian Ruker · Wien, AT
• Gottfried Himmler · Groß-Enzersdorf, AT
• Thomas Muster · Wien, AT
• Alexandra Trkola · Wien, AT
• Martin Purtscher · Wien, AT
• Georg Maiwald · Wien, AT
• Franz Steindl · Wien, AT

Key dates

• Filing date: Apr 17, 1997
• Grant date: Feb 2, 1999
• Expiry date: Apr 17, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention concerns peptides binding to antibodies which show neutralizing activity against different strains and clinical isolates of HIV-1 and which inhibit the fusion of cells infected with HIV-1. These peptides are combined with an adjuvant, as recombinant fusion proteins, chemically coupled to carrier molecules, as recombinant chimeric viruses or as recombinant antibodies.