Transgenic mice expressing TSSV40 large T antigen
US5866759A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 2, 1997 |
| Grant date | Feb 2, 1999 |
| Priority date | — |
| Expiry date | Jul 2, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2517/02
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
The provision of cell lines from virtually any cell type of the animal body is greatly facilitated by transgenic non-human eukaryotic animals of the invention in which at least some cells have (i) a differentiation inhibiting sequence chromosomally incorporated under the control of a non-constitutive promotor and/or (ii) a differentiation inhibiting sequence which is itself conditionally active. Said genes are chromosomally incorporated under the control of a promotor such that expression of said sequence is normally held below an effective level, thus allowing normal cell development. However, cells taken from said animal may be prevented from completing differentiation to a non-dividing state in tissue culture by activating expression of said sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.