Prevention of leakage and phase separation during thermotropic phase transition in liposomes and biological cells
US5869092A · kind A · utility
22Cited by
4References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 17, 1996 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Dec 17, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/43563
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Leakage from liposomes or biological cells and structural damage, which occur upon cooling through the thermotropic phase transition temperature and upon storage at temperatures below the phase transition temperature are reduced or eliminated by incorporating thermal hysteresis proteins in the liposome or cell structure. Preferred thermal hysteresis proteins are antifreeze proteins and antifreeze glycoproteins from polar fish species, and chromatographic fraction no. 8 of antifreeze glycoproteins has been found to be particularly effective.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.