Method of identifying compounds which modulate herpesvirus infection
US5869234A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 5, 1996 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Jan 5, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/91205
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method of identifying a compound which modulates (enhances, inhibits, reduces) herpesvirus infection of a vertebrate cell comprising the steps of combining a phosphorylating enzyme capable of catalyzing the phosphorylation of ICP4, a substrate comprising a polypeptide which is phosphorylated by the enzyme, a phosphate source and the compound to be assessed; maintaining the combination under conditions appropriate for phosphorylation of the substrate; and determining phosphorylation of the substrate which occurs in the presence of the compound to be assessed. The present invention also relates to the compounds identified by the methods of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.