Certain 3-ketosteroids used to inhibit steroid 5.alpha.-reductase
US5869475A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 1997 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Nov 14, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0066
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention discloses 3-ketosteroids of the following formula used to inhibit steroid 5.alpha.-reductase: ##STR1## wherein R is OH, C.sub.1 -C.sub.6 alkanoyl, C.sub.1 -C.sub.6 alkanoyloxy, C.sub.1 -C.sub.4 alkanol, COCH.sub.2 OH, CO.sub.2 H, CONR.sub.7 R.sub.8, cyclopropoxy, acetylthioalkane, cyclopylamino, 2-2-dimethyldioxolan-4-yl, 1,2-dihydroxyethyl and C.sub.1-4 alkanethiol; PA1 R.sub.1 is hydrogen, hydroxy or C.sub.1-6 alkyl; PA1 R.sub.1 and R.sub.2 together may indicate .dbd.O, that is an oxygen double bonded to the 17 carbon; PA1 R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or C.sub.1-6 alkyl; PA1 R.sub.5 and R.sub.6 are each independently hydrogen or OH; PA1 R.sub.5 and R.sub.6 together may indicate .dbd.O, that is an oxygen double bonded to the 11 carbon; PA1 R.sub.7 is hydrogen or C.sub.1-8 alkyl; PA1 R.sub.8 is C.sub.1-8 alkyl; and PA1 with the proviso that, when R is OH, then R.sub.1 is hydrogen; and with the proviso that, when R.sub.5 is OH, then R.sub.6 is hydrogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.