Fused pyrimidines and pyriazines as pharmaceutical compounds
US5869486A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 24, 1995 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Feb 24, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene; PA1 Z is bond, alkylene or vinylene; PA1 E is PA2 (i) 4-15 membered, unsaturated, partially saturated or fully saturated, mono or bicyclic hetero ring containing as hetero atoms, 1 or 2 N atoms, 1 or 2 O atoms or 1 S atom, PA2 (ii) 4-15 membered, unsaturated or partially saturated, mono or bicyclic carbocyclic ring, or PA2 (iii) --OR.sup.4 (in which R.sup.4 is hydrogen atom, alkyl or alkyl substituted by a hydroxy group); PA1 Cyc is 5-7 membered, unsaturated, partially saturated or fully saturated, monocyclic hetero ring containing as hetero atoms, 1 or 2 N atoms or 5-7 membered, unsaturated or partially saturated, monocyclic carbocyclic ring; PA1 R.sup.1 is H or alkyl; PA1 R.sup.2 is H, alkyl, alkoxy or halogen atom; PA1 R.sup.3 is H, alkyl, alkoxy or --COOR.sup.5 (in which R.sup.5 is H or alkyl); with the proviso that PA1 (1) a Cyc ring should not bond to Z through a nitrogen atom in the Cyc ring when Z is vinylene and that PA1 (2) Y is not a single bond, when E is --OR.sup.4 ; or pharmaceutically acceptable aci…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.