Terpenoidic derivatives useful as antitumor agents

US5869514A · kind A · utility

Assignee

• Pharmacia & Upjohn S.p.A. · IT

Inventors

• Carlo Battistini · Milano, IT
• Marina Ciomei · Corsico, IT
• Francesco Pietra · Lucca, IT
• Michele D'Ambrosio · Trento, IT
• Antonio Ricardo Leonardo Guerriero · Cranfield, GB

Key dates

• Filing date: Jan 15, 1997
• Grant date: Feb 9, 1999
• Expiry date: Jan 15, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating tumors in a human or animal by administering thereto a pharmaceutically effective amount of a Sarcodictyin compound selected from Sarcodictyin A, B, C, D, E, and F. Sarcodictyin A has the formula (-)-(4R,4aR,7R,10S,11S,12aR,1Z,5E,8Z)-7,10-Epoxy3,4,4a,7,10,11,12,12a-octa hydro-7-hydroxy-6-(methoxy-carbonyl)-1,10- dimethyl-4-(1-methylethyl)benzo cyclodecen-11-yl(E)-3-(1-Methyl-1H-imidazol-4-yl) acrylate (Sarcodictyin A).