4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones

US5869516A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Michael Arlt · Seeheim-Jugenheim, DE
• Rochus Jonas · Darmstadt, DE
• Maria Christadler · Darmstadt, DE
• Gunter Schneider · Reinheim, DE
• Michael Klockow · Lutherstadt Eisleben, DE

Key dates

• Filing date: May 16, 1996
• Grant date: Feb 9, 1999
• Expiry date: May 16, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

5-Pyrazolinone derivatives of the general formula I: ##STR1## in which the R.sup.1 -R.sup.3 variables are as defined herein and the physiologically acceptable salts thereof; processes for the preparation of these compounds, and in particular their use as selective inhibitors of cGMP-specific phosphodiesterase (cGMP PDE), thus as pharmaceutically active compounds.