Method for enhancing transport of gases to tissues

US5869538A · kind A · utility

Assignee

• Research Foundation for the State University of New York York · US

Inventors

• Hugh Van Liew · Orleans, US
• Mark E. Burkard · Rochester, US
• Clas E. G. Lundgren · Long Beach, US
• Ingvald M. Tyssebotn · Buffalo, US

Key dates

• Filing date: Nov 26, 1996
• Grant date: Feb 9, 1999
• Expiry date: Nov 26, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K33/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods of using stabilized microbubbles, such as those formulated from slowly permeating gas, to deliver or remove from tissue at least one gas selected from a respiratory gas, anesthetic gas, inert gas, or toxic gas. The methods comprise introducing, into the blood circulation of an individual to be treated, a therapeutically effective amount of the stabilized microbubbles. The methods are based on using the inherent physical properties of the blood circulation, of the microbubbles, and of the gases. The methods are especially useful for enhancing transport of oxygen in applications or conditions such as blood loss, anemia, organ perfusion, coronary Angioplasty, venous to arterial shunting of blood, oxygenation of ischemic tissues resulting from vascular obstructions, and oxygenation of solid tumor tissues in anticancer therapy.