Process for preparing polynucleotides on a solid support in a tightly packed bed
US5869643A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 14, 1994 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Dec 14, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B60/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for preparing polynucleotides on a solid support in a reactor in the form of a column through which solutions of reagents and/or solvents are circulated, wherein the solid phase constituting said solid support is immobilized in said reactor, and said solutions migrate in the column and through the solid phase according to a frontal progression, such that the successive solutions from each step of a synthesis cycle do not mix at all, or very little. The subject of the present invention is also a reactor consisting of a column completely filled with particles of porous materials constituting the solid support, and a synthesis device including such a reactor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.