Hydrogenation of nitriles to produce amines
US5869653A · kind A · utility
20Cited by
6References
24Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 30, 1997 |
| Grant date | Feb 9, 1999 |
| Priority date | — |
| Expiry date | Oct 30, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C209/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for the catalytic hydrogenation of nitriles. The basic process comprises contacting the nitrile with hydrogen in the presence of a sponge or Raney cobalt catalyst under conditions for effecting conversion of the nitrile group to the primary amine. The improvement in the hydrogenation process resides in effecting the hydrogenation in the presence of a catalytic amount of lithium hydroxide and water. To achieve a catalytic amount of lithium hydroxide, the catalyst may be pretreated with the lithium hydroxide and/or the reaction may be carried out with the lithium hydroxide present in the reaction medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.