Polyfunctional cationic cytofectins

US5869715A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael H. Nantz · Davis, US
• Michael Bennett · San Diego, US
• Rajiv P. Balasubramaniam · Davis, US

Key dates

• Filing date: Sep 27, 1995
• Grant date: Feb 9, 1999
• Expiry date: Sep 27, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C219/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

For use in transporting biologically active species into and through membrane barriers, a cationic amine compound is utilized that has the general structure: ##STR1## wherein R.sub.4 and R.sub.5 are a pair of same or different lipoyl moieties selected from a group consisting of an alkyl, alkenyl, alkynyl, alkanoyl, alkenoyl, or alkynoyl groups and for R.sub.1 R.sub.2, and R.sub.3 at least two are hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl groups or at least one amine bonded halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group or a mixture of at least one halogen containing moiety selected from a group consisting of a halogenated alkyl, alkenyl, or alkynyl group and at least one hydroxylated, ether containing, or acyloxy containing alkyl, alkenyl, or alkynyl group, and X.sup.- is an anion.