Methods for detecting calpain activation and identifying calpain inhibitors
US5871712A · kind A · utility
13Cited by
2References
6Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 26, 1996 |
| Grant date | Feb 16, 1999 |
| Priority date | — |
| Expiry date | Jan 26, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6896
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.