Controlled-release nifedipine
US5871776A · kind A · utility
Inventor
Key dates
| Filing date | Oct 28, 1996 |
| Grant date | Feb 16, 1999 |
| Priority date | — |
| Expiry date | Oct 28, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/4422
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A nifedipine formulation for oral administration is described that provides controlled, constant release of the pharmaceutical for about twenty four hours after a short delay following oral administration. There is also provided a method for preparing a controlled release formulation of nifedipine, which method includes coating pellets with multiple nifedipine-containing layers, along with an outer controlled release coating comprised of a water permeable polymer and lubricant/glidant. The pellets are then cured at an elevated temperature over several days. A method of using the formulations of the present invention for the treatment of patients is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.