Assays for modulators of drosophila cation channel function
US5871940A · kind A · utility
4Cited by
4References
13Claims
0Family size
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Key dates
| Filing date | Jan 13, 1997 |
| Grant date | Feb 16, 1999 |
| Priority date | — |
| Expiry date | Jan 13, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/43581
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Genomic and cDNA clones corresponding to the tipE gen of Drosophila melanogaster are described. The tipE protein functions in concert with the para gene product, a polypeptide which exhibits similarity to mammalian voltage-dependent sodium channel .alpha. subunits but is not by itself functional. Coexpression of the tipE and para genes in a host cell affords functional cation channels. The invention accordingly provides screening assays for modulators of Drosophila cation channels employing cells expressing both tipE and para polypeptides, useful inter alia to evaluate candidate pesticidal agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.