Mutant rev genes encoding transdominant repressors of HIV replication
US5871958A · kind A · utility
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4References
27Claims
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Key dates
| Filing date | Nov 3, 1994 |
| Grant date | Feb 16, 1999 |
| Priority date | — |
| Expiry date | Nov 3, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16322
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example, protect cells against the deleterious effects of viral, e.g. HIV-1, infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.