Specific binding members, materials and methods
US5872215A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | May 23, 1996 |
| Grant date | Feb 16, 1999 |
| Priority date | — |
| Expiry date | May 23, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/735
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Specific binding members for human carcinoembryonic antigen (CEA) comprise a human antibody antigen binding domain. The specific binding members may have a dissociation constant less than 1.0.times.10.sup.-8 M and may be substantially non-crossreactive with human liver and/or other normal tissues. They may be specific for the A3-B3 extracellular domain of CEA. They may be specific for a carbohydrate epitope of CEA. They may be produced by recombinant expression from encoding nucleic acid and modified and manipulated in various manners in accordance with known techniques. CEA is a tumour antigen and the specific binding members have proven ability to bind and target CEA both in vitro and in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.