Human platelet-derived growth factor receptor extracellular domain antibodies

US5872218A · kind A · utility

Assignees

• COR Therapeutics, Inc. · US
• The Regents of the University of California · US

Inventors

• David L. Wolf · Palo Alto, US
• James E. Tomlinson · Horsham, GB
• Larry J. Fretto · Palo Alto, US
• Neill A. Giese · San Francisco, US
• Jaime Escobedo · San Francisco, US
• Lewis T. Williams · San Francisco, US

Key dates

• Filing date: Jun 2, 1995
• Grant date: Feb 16, 1999
• Expiry date: Jun 2, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides antibodies that bind to epitopes of human platelet-derived growth factor receptor (hPDGF-R) fragments, wherein the fragments comprise one or more platelet-derived growth factor (PDGF) ligand binding regions from extracellular domains D1, D2, and D3. Also provided are antibodies specific for domain D3, such as monoclonal antibodies directed to the intra-cysteine portion of domain D3.