Megabase transcript map: novel sequences and antibodies thereto

US5872237A · kind A · utility

Assignee

• Mercator Genetics, Inc. · US

Inventors

• John Feder · Montgomery, US
• Gregory Scott Kronmal · Pacifica, US
• Peter Lauer · Albany, US
• David Ruddy · San Francisco, US
• Winston J. Thomas · San Mateo, US
• Zenta Tsuchihashi · Menlo Park, US
• Roger K. Wolff · Mill Valley, US

Key dates

• Filing date: Oct 1, 1996
• Grant date: Feb 16, 1999
• Expiry date: Oct 1, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A fine structure map of the 1 megabase region surrounding the candidate HH gene is provided, along with 250 KB of DNA sequence and 8 loci corresponding to candidate genes within the 1 megabase region. These loci are useful as genetic markers for further mapping studies. Additionally, the eight cDNA sequences corresponding to those loci are useful, for example, for the isolation of other genes in putative gene families, and as probes for diagnostic assays. Additionally, the proteins encoded by those cDNAs are useful in the generation of antibodies for analysis of gene expression and in diagnostic assays, and in the purification of related proteins.