Caged nucleotides
US5872243A · kind A · utility
26Cited by
3References
27Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jun 30, 1995 |
| Grant date | Feb 16, 1999 |
| Priority date | — |
| Expiry date | Jun 30, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD.sup.+, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the present compounds allows the release of the free nucleotide in vivo or in vitro with precise spatial and temporal control. The compounds are useful for the photolytic generation of free nucleotides in aqueous samples, for example, in the study of calcium mobilization in cells and cell homogenates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.