Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes

US5874061A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Heribert Schmitt-Willich · Berlin, DE
• Johannes Platzek · Berlin, DE
• Bernd Raduchel · Berlin, DE
• Hanns-Joachim Weinmann · Berlin, DE
• Wolfgang Ebert · Krefeld, DE
• Bernd Misselwitz · Berlin, DE
• Andreas Muhler · Oderberg, DE
• Thomas Frenzel · Berlin, DE

Key dates

• Filing date: Dec 20, 1996
• Grant date: Feb 23, 1999
• Expiry date: Dec 20, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K51/065
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cascade polymer complexes that contain PA1 a) complexing ligands of general formula I EQU A--{X--Y--(Z--(W--K.sub.w).sub.z).sub.y!.sub.x }.sub.a, (I) PA1 in which PA2 A stands for a nitrogen-containing cascade nucleus of base multiplicity a, PA2 X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, PA2 Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, PA2 K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, PA1 provided that at least two reproduction units are different, that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64 holds true for the product of the multiplicities, and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane reproduction unit, PA1 b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, PA1 c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as PA1 d) opti…