Synthesis and use for the treatment of osteoporosis
US5874086A · kind A · utility
34Cited by
16References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 1994 |
| Grant date | Feb 23, 1999 |
| Priority date | — |
| Expiry date | Jan 18, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: EQU Haa(Laa Laa Haa Haa).sub.2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.